Participants Needed For Drooling Study At USC

conducting research

A research study is being conducted at the University of Southern California (USC) to evaluate an investigational product for the treatment of troublesome drooling (sialorrhea).

Eligibility criteria:

– diagnosis of Parkinson’s disease, multiple sclerosis, stroke, traumatic brain injury, or other condition that causes excessive drooling
– between the ages of 18 and 85 years old

Study-related care and medical exams are provided at no charge and you will be compensated for your time and effort.

For more information or to enroll in the study, please call Gina Barles, Clinical Project Manager, Division of Movement Disorders, Neurology, USC, at 323-442-5723

Participants Needed for Drooling Study at USC:

US WorldMeds has launched a Phase III clinical trial studying the use of MYOBLOC® (rimabotulinumtoxinB) Injection for the treatment of sialorrhea in adults, with a goal of obtaining FDA approval for this indication. Commonly known as “drooling,” sialorrhea frequently occurs in patients who may have difficulty swallowing due to neurological disorders such as Parkinson’s disease, Lou Gehrig’s disease, stroke, brain injury and cerebral palsy. Drooling can also be caused by oral cancers or as a side effect to certain medications, such as drugs used to treat Schizophrenia.

MYOBLOC is currently FDA-approved and indicated for the treatment of adults with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.

MYOBLOC has also been studied in several prior clinical trials in the United States as reported in published manuscripts, including an earlier Phase II study of 54 Parkinson’s disease patients with sialorrhea.

This MYOBLOC trial is a nationwide, multicenter, double-blinded, placebo-controlled study that will enroll patients who have been diagnosed with sialorrhea due to multiple causes. MYOBLOC will be injected directly into the salivary glands, and the efficacy and safety will be analyzed over the course of 1 year. When MYOBLOC is injected directly into the salivary glands, it inhibits the release of the neurotransmitter acetylcholine, resulting in decreased saliva production, thereby decreasing drooling. is an excellent resource to learn about clinical trials, considerations for participation, questions to ask the research team and your personal physician, and how participants are protected.

The NeuroCommunity Foundation strongly recommend you discuss participation in a clinical trial with your doctor and make sure you understand the informed consent document.

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For information about neurological disorders, support groups, wellness programs, education events, and local resources in northern Los Angeles county, Ventura county, Central Coast & Central Valley, contact us here or call 818-885-8623 to speak with Viviane Tondeur, Education Director, The NeuroCommunity Foundation.

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